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Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T07A003, September 11–13, 2013

Paper No: FMD2013-16165

DOI: https://doi.org/10.1115/FMD2013-16165

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Topics: Biological tissues, Flow (Dynamics), Modeling, Stem cells, Tissue engineering, Valves, Bioreactors, Computational fluid dynamics, Bioengineering, Boundary-value problems

Proceedings Papers

Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation

João S. Soares, Trung B. Le, Fotis Sotiropoulos, Michael S. Sacks

Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT15A001, June 26–29, 2013

Paper No: SBC2013-14180

DOI: https://doi.org/10.1115/SBC2013-14180

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Topics: Biological tissues, Shear stress, Simulation, Stem cells, Valves, Biodegradation, Bone, Hemodynamics, Maintenance, Pediatrics

Journal Articles

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering

João S. Soares, Trung B. Le, Fotis Sotiropoulos, Michael S. Sacks

J. Med. Devices. December 2013, 7(4): 040927.

Paper No: MED-13-1248

DOI: https://doi.org/10.1115/1.4025984

Published Online: December 5, 2013

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Topics: Biological tissues, Flow (Dynamics), Modeling, Stem cells, Tissue engineering, Valves

Proceedings Papers

Phase-Locked PIV Measurement in the Wake of Model Wind Turbines Under Various Inflow Conditions

David J. Green, Leonardo P. Chamorro, Roger E. Arndt, Fotis Sotiropoulos, Jian Sheng

Proc. ASME. FEDSM2012, Volume 1: Symposia, Parts A and B, 1507-1514, July 8–12, 2012

Paper No: FEDSM2012-72331

DOI: https://doi.org/10.1115/FEDSM2012-72331

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Topics: Inflow, Wakes, Wind turbines, Turbines, Flow (Dynamics), Turbulence, Rotors, Wake turbulence, Boundary layer turbulence, Boundary layers

Proceedings Papers

CFD Challenge: Computational Hemodynamics Analysis of Patient-Specific Internal Carotid Artery Aneursym Using an In-House Finite Difference Cardiovascular Flow Solver

Prahlad G. Menon, Fotis Sotiropoulos, Kerem Pekkan

Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 131-132, June 20–23, 2012

Paper No: SBC2012-80457

DOI: https://doi.org/10.1115/SBC2012-80457

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Topics: Cardiovascular system, Carotid arteries, Computational fluid dynamics, Flow (Dynamics), Hemodynamics, Internal flow, Aneurysms, Aortic arch, Engineering simulation, Fluid mechanics

Proceedings Papers

Device Specific Aortic Outflow Cannula Jets Studied Using 2D PIV and High-Performance 3D CFD Simulation

Prahlad G. Menon, Nikola Teslovich, Chia-Yuan Chen, Fotis Sotiropoulos, Akif Undar, Kerem Pekkan

Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 67-68, June 20–23, 2012

Paper No: SBC2012-80454

DOI: https://doi.org/10.1115/SBC2012-80454

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Topics: Computational fluid dynamics, Jets, Outflow, Simulation, Blood, Flow (Dynamics), Blood flow, Surgery, Wakes, Circuits

Proceedings Papers

Development of an Anatomically Realistic Left Ventricle Physical Model and Multi-Modality Experimental Platform for Validation of Patient-Specific Computational Simulations

Brandon Chaffins, Trung Le, Arvind Santhanakrishnan, Lucia Mirabella, Fotis Sotiropoulos, Ajit Yoganathan

Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 567-568, June 20–23, 2012

Paper No: SBC2012-80613

DOI: https://doi.org/10.1115/SBC2012-80613

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Topics: Engineering simulation, Simulation, Computational fluid dynamics, Diseases, Flow (Dynamics), Bioengineering, Biomedicine, Deformation, Dynamics (Mechanics), Food and Drug Administration

Journal Articles

High Resolution Simulation of Tri-Leaflet Aortic Heart Valve in an Idealized Aorta

Trung Bao Le, Anvar Gilmanov, Fotis Sotiropoulos

J. Med. Devices. September 2013, 7(3): 030930.

Paper No: MED-13-1088

DOI: https://doi.org/10.1115/1.4024520

Published Online: July 3, 2013

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Topics: Aorta, Resolution (Optics), Simulation, Valves, Flow (Dynamics)

Journal Articles

A Process for Design, Verification, Validation, and Manufacture of Medical Devices Using Immersive VR Environments

Daniel F. Keefe, Fotis Sotiropoulos, Victoria Interrante, H. Birali Runesha, Dane Coffey, Molly Staker, Chi-Lun Lin, Yi Sun, Iman Borazjani, Trung Le, Nancy Rowe, Arthur Erdman

J. Med. Devices. December 2010, 4(4): 045002.

DOI: https://doi.org/10.1115/1.4002561

Published Online: November 3, 2010

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Topics: Computational fluid dynamics, Design, Medical devices, Simulation, Visualization, Valves, Virtual reality, Engineering simulation, Computers

Journal Articles

Pulsatile Flow Effects on the Hemodynamics of Intracranial Aneurysms

Trung B. Le, Iman Borazjani, Fotis Sotiropoulos

J Biomech Eng. November 2010, 132(11): 111009.

DOI: https://doi.org/10.1115/1.4002702

Published Online: October 27, 2010

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Topics: Aneurysms, Domes (Structural elements), Flow (Dynamics), Hemodynamics, Vortices, Shear stress, Cavities, Inflow, Pulsatile flow, Reynolds number

Journal Articles

The Effect of Implantation Orientation of a Bileaflet Mechanical Heart Valve on Kinematics and Hemodynamics in an Anatomic Aorta

Iman Borazjani, Fotis Sotiropoulos

J Biomech Eng. November 2010, 132(11): 111005.

DOI: https://doi.org/10.1115/1.4002491

Published Online: October 15, 2010

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Topics: Aorta, Flow (Dynamics), Heart valve prostheses, Hemodynamics, Kinematics, Shear stress, Simulation, Valves, Magnetic resonance imaging, Fluid structure interaction

Journal Articles

Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?

Liang Ge, Fotis Sotiropoulos

J Biomech Eng. January 2010, 132(1): 014505.

DOI: https://doi.org/10.1115/1.4000162

Published Online: December 9, 2009

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Topics: Blood flow, Flow (Dynamics), Hemodynamics, Shear stress, Valves, Endothelial cells

Proceedings Papers

Experimental and Computational Studies of Chaotic Stirring in Complex 3D Flows

Fotis Sotiropoulos, Tahirih C. Lackey, S. Casey Jones

Proc. ASME. FEDSM2002, Volume 1: Fora, Parts A and B, 1493-1500, July 14–18, 2002

Paper No: FEDSM2002-31357

DOI: https://doi.org/10.1115/FEDSM2002-31357

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Topics: Flow (Dynamics), Swirling flow, Computation, Confined flow, Containers, Ergodic theory, Particulate matter, Reynolds number, Vortices

Journal citation

NARROW

Experimental Visualization of Lagrangian Coherent Structures in Aperiodic Free Surface Flow

A Non-Intrusive Experimental Technique for Constructing Poincaré Maps in 3D Chaotically Advected Flows

The Lagrangian Dynamics of Steady Vortex Breakdown Bubbles

Flow–Structure Interaction Simulations of the Aortic Heart Valve at Physiologic Conditions: The Role of Tissue Constitutive Model

Vortex Dynamics in Sidewall Aneurysms: Hemodynamic Transition During Growth and Clinical Implications

A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions

Simulations of the Hinge Flow Fields of a Bileaflet Mechanical Heart Valve Under Physiologic Pulsatile Aortic Conditions

Modeling the Role of Oscillatory Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell Derived Heart Valve Tissue Engineering

Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering

Phase-Locked PIV Measurement in the Wake of Model Wind Turbines Under Various Inflow Conditions

CFD Challenge: Computational Hemodynamics Analysis of Patient-Specific Internal Carotid Artery Aneursym Using an In-House Finite Difference Cardiovascular Flow Solver

Device Specific Aortic Outflow Cannula Jets Studied Using 2D PIV and High-Performance 3D CFD Simulation

Development of an Anatomically Realistic Left Ventricle Physical Model and Multi-Modality Experimental Platform for Validation of Patient-Specific Computational Simulations

High Resolution Simulation of Tri-Leaflet Aortic Heart Valve in an Idealized Aorta

A Process for Design, Verification, Validation, and Manufacture of Medical Devices Using Immersive VR Environments

Pulsatile Flow Effects on the Hemodynamics of Intracranial Aneurysms

The Effect of Implantation Orientation of a Bileaflet Mechanical Heart Valve on Kinematics and Hemodynamics in an Anatomic Aorta

Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?

Experimental and Computational Studies of Chaotic Stirring in Complex 3D Flows

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