Precision medicine is an emerging healthcare delivery approach that considers variability between patients, such as genetic makeups, in contrast to the current one-size-fits-all approach that is designed to treat the average patient. The White House launched the Precision Medicine Initiative in 2015, starting an endeavor to reshape healthcare delivery. To translate the concept of precision medicine from the bench to practice, advanced manufacturing will play an integral part, including the fabrication of personalized drugs and drug delivery devices and drug screening platforms. These products are highly customized and require robust yet flexible manufacturing systems. The advanced manufacturing field has rapidly evolved in the past five years. In this state-of-the-art review, products manufactured for precision medicine will be introduced, followed by a brief review of processing materials and their characteristics. A review on different manufacturing processes applicable to those aforementioned products is provided. The current status of the development of regulatory submission and quality control considerations are also discussed. Finally, this paper presents a future outlook on manufacturing processes used for precision medicine.