...Martin Kroon A theoretical model for the remodeling of collagen gels is proposed. The collagen fabric is modeled as a network of collagen fibers, which in turn are composed of collagen fibrils. In the model, the strengthening of collagen fabric is accomplished by fibroblasts, which continuously...

... biological tissues biomechanics elasticity gels physiological models surgery vibrations wounds mechanical larynx surgical experimentation vocal fold substitute agarose The purpose of this study is to develop a simple and robust mechanical model of the larynx that enables surgeons...

... of this technique. In this paper, we analyze experimentally the force impact of high flow microinfusion on the deformable gel matrix. To investigate these fluid structure interactions, two optical methods are reported. First, gel stresses during microinfusion were visualized through a linear polariscope. Second...

...Julia Raykin; Alexander I. Rachev; Rudolph L. Gleason, Jr. Mechanical stimulation has been shown to dramatically improve mechanical and functional properties of gel-derived tissue engineered blood vessels (TEBVs). Adjusting factors such as cell source, type of extracellular matrix, cross-linking...

... to describe mechanically because of the ability of the cells to remodel the matrix, including compaction at short times and synthesis and/or degradation (and cell proliferation) at longer times. The objectives of this work were to measure the equilibrium modulus of fibroblast-populated gels with different...

...Eduardo Reátegui; Alptekin Aksan Proteins and enzymes can be encapsulated in nanoporous gels to develop novel technologies for biosensing, biocatalysis, and biosynthesis. When encapsulated, certain macromolecules retain high levels of activity and functionality and are more resistant...

.... For the construction of the gel structure, sodium alginate solution was ejected from the inkjet nozzle (SEA-Jet™, Seiko Epson Corp., Suwa, Japan) and was mixed with a substrate composed of a calcium chloride solution. In our 3D bioprinter, the nozzle head can be moved in three dimensions. Owing to the development...

... behavior of the regenerated cartilaginous tissue, because these tissues need to bear various dynamic loadings in daily life. The objectives of this study were to evaluate in detail the dynamic viscoelastic responses of chondrocyte-seeded agarose gel cultures in compression and torsion (shear...

... constructs respond to in vitro mechanical stimulation. Although one study showed that stimulating mesenchymal stem cell (MSC)–collagen sponge constructs significantly increased construct linear stiffness and repair biomechanics, a second study showed no such effect when a collagen gel replaced the sponge...

... their stiffness and modulus in culture and tendon repair biomechanics 12 weeks after surgical implantation. Using six female adult New Zealand White rabbits, autogenous tissue engineered constructs were created by seeding mesenchymal stem cells ( 0.1 × 10 6 cells ∕ ml ) in collagen gel ( 2.6 mg ∕ ml...

... the tissue structures and their mechanical behavior. We used a novel collagen gel system to test the hypothesis that collagen fiber alignment is the primary mechanism for the mechanical anisotropy we have reported in structurally anisotropic gels. Loading constraints applied during culture were used...

... represented as a hydrated gel surrounded by a semi-permeable membrane, with the gel and membrane potentially exhibiting different properties. To help assess whether this more elaborate model of the cell is justified, this study investigates the response of spherical gels to osmotic loading, both from...

... compression data were obtained from testing polyvinyl alcohol gels of known composition. Local elastic properties of tissue-engineered cartilage were also measured by the AFM. All AFM data sets were processed using customized software based on the algorithm, and the extracted values of Young’s modulus were...

...Stavros Thomopoulos; Gregory M. Fomovsky; Jeffrey W. Holmes An in vitro model system was developed to study structure-function relationships and the development of structural and mechanical anisotropy in collagenous tissues. Fibroblast-populated collagen gels were constrained either biaxially...

... set of material parameters. The material parameters which best fit the FEM predicted displacements to the displacements reconstructed from the tagged images were found by nonlinear optimization. The equipment and method were validated using inflation of a deformable silicon gel phantom in the shape...

... Spine Intervertebral Disc Nucleus Pulposus Hydrogel Nucleus Implant Compressive Stiffness Lower Back Pain bone neurophysiology orthopaedics gels biomedical materials biomechanics prosthetics compressive testing 27 09 2003 27 11 2004 31 01 2005 An Instron...

...Jeanie L. Drury; Tanyarut Boontheekul; David J. Mooney Peptide modification of hydrogel-forming materials is being widely explored as a means to regulate the phenotype of cells immobilized within the gels. Alternatively, we hypothesized that the adhesive interactions between cells and peptides...

... tissue engineering biotransport modelling biomechanics biorheology porous materials gels permeability biodiffusion biological tissues convection biomedical materials 27 09 2004 2004 ASME ...

...Robert L. Mauck,; Clark T. Hung, and; Gerard A. Ateshian 24 06 2004 gels permeability biodiffusion biological tissues biomechanics convection porous materials biomedical materials Typesetting corrections for Eqs. ( 32 ), ( 48 ), and ( 49 ): (32) u r r , 0...

...Preethi L. Chandran; Victor H. Barocas Background: Collagen gels are important as platforms for in vitro study of cell behavior and as prototypical bioartificial tissues, but their mechanical behavior, particularly on the microscopic scale, is still poorly understood. Method of Approach: Collagen...