A two-dimensional axisymmetric computer model is developed for the simulation of the filling flow in the left ventricle (LV). The computed results show that vortices are formed during the acceleration phases of the filling waves. During the deceleration phases these are amplified and convected into the ventricle. The ratio of the maximal blood velocity at the mitral valve (peak E velocity) to the flow wave propagation velocity (WPV) of the filling wave is larger than 1. This hemodynamic behavior is also observed in experiments in vitro (Steen and Steen, 1994, Cardiovasc. Res., 28, pp. 1821–1827) and in measurements in vivo with color M-mode Doppler echocardiography (Stugaard et al., 1994, J. Am. Coll. Cardiol., 24, 663–670). Computed intraventricular pressure profiles are similar to observed profiles in a dog heart (Courtois et al., 1988, Circulation, 78, pp. 661–671). The long-term goal of the computer model is to study the predictive value of noninvasive parameters (e.g., velocities measured with Doppler echocardiography) on invasive parameters (e.g., pressures, stiffness of cardiac wall, time constant of relaxation). Here, we show that higher LV stiffness results in a smaller WPV for a given peak E velocity. This result may indicate an inverse relationship between WPV and LV stiffness, suggesting that WPV may be an important noninvasive index to assess LV diastolic stiffness, LV diastolic pressure and thus atrial pressure (preload). [S0148-0731(00)01606-X]
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December 2000
Technical Papers
Computer Simulation of Intraventricular Flow and Pressure Gradients During Diastole
J. A. Vierendeels,
J. A. Vierendeels
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
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K. Riemslagh,
K. Riemslagh
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
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E. Dick, Mem. ASME,
E. Dick, Mem. ASME
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
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P. R. Verdonck
P. R. Verdonck
Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
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J. A. Vierendeels
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
K. Riemslagh
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
E. Dick, Mem. ASME
Department of Flow, Heat, and Combustion Mechanics, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
P. R. Verdonck
Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, St.-Pietersnieuwstraat 41, 9000 Ghent, Belgium
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division May 18, 1999; revised manuscript received July 9, 2000. Associate Technical Editor: C. R. Ethier.
J Biomech Eng. Dec 2000, 122(6): 667-674 (8 pages)
Published Online: July 9, 2000
Article history
Received:
May 18, 1999
Revised:
July 9, 2000
Citation
Vierendeels , J. A., Riemslagh , K., Dick, E., and Verdonck, P. R. (July 9, 2000). "Computer Simulation of Intraventricular Flow and Pressure Gradients During Diastole ." ASME. J Biomech Eng. December 2000; 122(6): 667–674. https://doi.org/10.1115/1.1318941
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