Highly localized long-term measurements of tumor transport properties are performed with pairs of adjacent, parallel single-strand optic fibers embedded in a laboratory animal. External illumination and light sensing equipment detect local concentration of a fluorescent indicator initially injected into the venous system. Under appropriate conditions, blood flow per unit volume, capillary permeability, and uptake of fluorescent drugs can be determined from the fluorescence time history. The observation volume has a characteristic dimension on the order of 0.5 mm. Chronic tests in 20 animals monitored for 1–2 weeks have demonstrated that the technique is practical, the tumor histology is acceptable, and the measured local tissue uptake is comparable to average values in the literature. The technique is also suitable for acute experiments using a miniature fiber optic needle probe.
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August 1980
Research Papers
Fiber Optic Microfluorimetry for Acute and Chronic In-Vivo Animal Studies
S. R. Goldstein,
S. R. Goldstein
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
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R. F. Bonner,
R. F. Bonner
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
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R. L. Dedrick,
R. L. Dedrick
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
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F. H. Grantham,
F. H. Grantham
Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20205
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P. M. Gullino,
P. M. Gullino
Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20205
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C. C. Gibson,
C. C. Gibson
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
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D. A. McGuire
D. A. McGuire
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
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S. R. Goldstein
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
R. F. Bonner
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
R. L. Dedrick
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
F. H. Grantham
Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20205
P. M. Gullino
Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20205
C. C. Gibson
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
D. A. McGuire
Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, Md. 20205
J Biomech Eng. Aug 1980, 102(3): 265-273 (9 pages)
Published Online: August 1, 1980
Article history
Received:
October 29, 1979
Revised:
May 1, 1980
Online:
June 15, 2009
Citation
Goldstein, S. R., Bonner, R. F., Dedrick, R. L., Grantham, F. H., Gullino, P. M., Gibson, C. C., and McGuire, D. A. (August 1, 1980). "Fiber Optic Microfluorimetry for Acute and Chronic In-Vivo Animal Studies." ASME. J Biomech Eng. August 1980; 102(3): 265–273. https://doi.org/10.1115/1.3149584
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