Discussion of “Cytoskeletal Mechanics Regulating Amoeboid Cell Locomotion” (Álvarez-González, B., Bastounis, E., Meili, R., del Alamo, J. C., Firtel, R. A., and Lasheras, J. C., 2014, ASME Appl. Mech. Rev., 66(5), p. 050804)

[+] Author and Article Information
Xavier Trepat

Institute for Bioengineering of Catalonia,
Barcelona, Spain
Unitat de Biofísica i Bioenginyeria,
Facultat de Medicina,
Universitat de Barcelona and CIBERES,
Barcelona, Spain
Institució Catalana de Recerca i Estudis
Avançats (ICREA),
Barcelona, Spain
e-mail: xtrepat@ibecbarcelona.eu

Manuscript received January 30, 2014; final manuscript received February 28, 2014; published online June 5, 2014. Editor: Harry Dankowicz.

Appl. Mech. Rev 66(5), 055502 (Jun 05, 2014) (2 pages) Paper No: AMR-14-1014; doi: 10.1115/1.4027258 History: Received January 30, 2014; Revised February 28, 2014

A virtually universal feature of adherent cells is their ability to exert traction forces. To measure these forces, several methods have been developed over the past 15 years. In this issue of Applied Mechanics Reviews, Álvarez-González and co-workers review their own traction force microscopy approach and its application to the study of amoeboid cell locomotion. They show that the cycle of cell motility is exquisitely synchronized by a cycle of traction forces. In addition, they show how traction forces and cell cycle synchronization are affected by myosin and SCAR/WAVE mutants. Here, I discuss some open questions that derive from the work of the authors and other laboratories as regards the relationship between cell motility and traction forces.

Copyright © 2014 by ASME
Topics: Traction , Microscopy
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