Review Articles

Review on the Constitutive Models of Tumor Tissue for Computational Analysis

[+] Author and Article Information
G. U. Unnikrishnan, V. U. Unnikrishnan, J. N. Reddy

Department of Mechanical Engineering, Advanced Computational Mechanics Laboratory, Texas A&M University, College Station, TX 77843-3123

C. T. Lim

Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore

Appl. Mech. Rev 63(4), 040801 (Oct 27, 2010) (7 pages) doi:10.1115/1.4002427 History: Received April 07, 2010; Revised August 03, 2010; Published October 27, 2010; Online October 27, 2010

A study on the constitutive models of tumor tissues is critical for the advancement of computational tools for clinical diagnosis and treatment plans. In this respect, continuum based constitutive models of tumor tissues applied in the computational analysis of tumor tissues are reviewed in this work. An introduction to the continuum based computational modeling of tumor tissue and a brief review of the applications of computational models in tumor diagnosis and treatment plans are presented in Sec. 1. The pathophysiology of tumor is given in Sec. 2. Continuum based constitutive models of tumor tissues are reviewed in Sec. 3 and in Sec. 4, conclusions and recommendations for the future development of tumor constitutive model are presented. It is the aim of the authors to provide a comprehensive study on the various constitutive models of tumors to enhance the application of biomechanical simulation of tumor tissues.

Copyright © 2010 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

Different stages in the development of cancerous cell from a normal cell

Grahic Jump Location
Figure 2

Tumor tissue development from an initial growth phase to the malignant phase

Grahic Jump Location
Figure 3

Schematic representation of heterogeneous tumor tissue showing spatial variation of cancer cell, interstitium, and vascular tissues



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