REVIEW ARTICLES: Mechanics Applied to Living Organisms

Arterial Fluid Mechanics and Biological Response

[+] Author and Article Information
M. H. Friedman

Biomedical Engineering Center, The Ohio State University, Columbus, OH 43210

Appl. Mech. Rev 43(5S), S103-S108 (May 01, 1990) doi:10.1115/1.3120788 History: Online April 30, 2009


To better understand the response of the arterial wall to the adjacent blood flow, corresponding hemodynamic and histomorphometric data are obtained at multiple sites in human arteries. The hemodynamic data are obtained by perfusing realistically compliant flow-through casts of vascular segments with physiologically realistic pulsatile flows and measuring near-wall velocities by laser Doppler velocimetry. The hemodynamic and histologic data in combination suggest that the thickening response of the innermost layer of the vessel wall, which may precede atherosclerosis at the site, varies with time and wall shear: at early times, sites exposed to relatively high and unidirectional shears are thicker, while at later times, their thickness is exceeded by that at sites exposed to relatively low or oscillatory shear forces. A biologically plausible mathematical model of the thickening process supports the hypothesis that this behavior can be the consequence of multiple shear-dependent processes in the vessel wall.

Copyright © 1990 by American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In