The placental membranes, which surround the fetus in utero, are made of chorioamnion (CA) — a composite bilayered structure made of amnion and chorion. The CA is the only tissue in the body designed to fail, yet early CA failure causes preterm birth and is associated with elevated infant morbidity and mortality 1. While the elastic moduli, E, of the chorion and the amnion have been independently investigated 1,2,3, how these two layers work together in the composite CA bilayer has yet to be thoroughly investigated.
- Bioengineering Division
The Rule of Mixtures: Approximating Chorioamnion Elastic Modulus in Human Placental Membranes
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Barnard, CA, Briggs, BN, & Ferguson, VL. "The Rule of Mixtures: Approximating Chorioamnion Elastic Modulus in Human Placental Membranes." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT59A009. ASME. https://doi.org/10.1115/SBC2013-14692
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