Microbeads are three-dimensional, generally spherical microstructures that are currently being investigated for applications in tissue engineering and for delivery of drugs, proteins, and DNA [1, 2]. Current microbead fabrication devices such as electrostatic bead generators, microfluidic devices, and micro-vibrators, function by using cross-linkable polymers into a crosslinking solution, such as calcium chloride in the case of alginate. These procedures allow for the controlled manipulation of microbead size, e.g., increasing electric field voltage for the electrostatic bead generator during polymer extrusion. Popular devices such as electrostatic bead generators are limited to polyelectrolyte materials because of the electric field extrusion method . In addition, despite their ability to create monodispersed beads of different size, none of these technologies can precisely control microbead placement.
- Bioengineering Division
A Novel, Laser-Based Technique to Fabricate and Precisely Pattern Cell-Encapsulated Alginate Microbeads
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Kingsley, DM, Dias, AD, Chrisey, DB, & Corr, DT. "A Novel, Laser-Based Technique to Fabricate and Precisely Pattern Cell-Encapsulated Alginate Microbeads." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT58A009. ASME. https://doi.org/10.1115/SBC2013-14658
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