Biomaterial scaffolds that present defined microenvironmental cues (e.g., nano-topography) to cells have shown promise for a variety of tissue engineering applications. However, the specific cues best suited for promoting the formation of aligned, fibrous tissues such as tendon are not fully understood. In this study, we utilize a micro-photopatterning (μPP) model system to precisely arrange scaffold-mimicking microenvironmental cues and investigate their role in the formation of tendon-like neo-tissues. Our data show that scaffold architectural features at both nano- and micro-length scales may be important parameters for directing tendon-like cell organization and the formation of aligned, fibrillar collagen.
- Bioengineering Division
Nano-Scale and Micro-Scale Substrate Architectures Direct Collagen Alignment in Tendon Neo-Tissue Formation
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Gilchrist, CL, Ruch, DS, Little, D, & Guilak, F. "Nano-Scale and Micro-Scale Substrate Architectures Direct Collagen Alignment in Tendon Neo-Tissue Formation." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT39A005. ASME. https://doi.org/10.1115/SBC2013-14474
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