Cardiovascular tissues have a prominent load-bearing function. Collagen fibers in the extracellular matrix provide strength to these tissues. In particular the content and organization of these fibers contribute to overall strength . In case of changes in mechanical demand, collagen content and organization can be adapted; a process referred to as collagen remodeling. For the creation of engineered cardiovascular tissues knowledge about collagen remodeling is of utmost importance to produce tissues with load bearing function. In case of in situ tissue engineering (TE) collagen content and organization in the developing tissue can be influenced by local tissue strains as well as scaffold structure and degradation properties [2, 3].
- Bioengineering Division
Influence of Strain and Contact Guidance on Collagen Organization in Engineered Cardiovascular Tissues: Implications for In Situ Tissue Engineering
- Views Icon Views
- Share Icon Share
- Search Site
de Jonge, N, Argento, G, Baaijens, FPT, & Bouten, CVC. "Influence of Strain and Contact Guidance on Collagen Organization in Engineered Cardiovascular Tissues: Implications for In Situ Tissue Engineering." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT28A001. ASME. https://doi.org/10.1115/SBC2013-14242
Download citation file: