Aortic aneurysms affect approximately 5% of the elderly population and aneurysm rupture is responsible for a significant number of deaths in the western world. Risk factors for aortic aneurysm include high cholesterol, high blood pressure, and smoking. Fibulin-4 is a glycoprotein, which is expressed in medial layers of blood vessels and a critical component for the structural integrity and elasticity of the aortic wall [1]. Mice with reduced levels of Fibulin-4 develop aortic abnormalities similar to Fibulin-4 patients, such as dilation of the ascending aorta. A 4-fold reduction of Fibulin-4 expression (fib-4R/R) causes a severe dilation, while a mice with a 2-fold reduction (fib-4+/R) show an onset of aneurysm formation, comparable with the development of an aneurysm in aging humans [2].
Skip Nav Destination
ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Biomechanical Characteristics of Aortic Aneurysms Generated in Fibulin-4 Deficient Mice
L. Speelman,
L. Speelman
Erasmus MC, Rotterdam, The Netherlands
ICIN, Netherlands Heart Institute, Utrecht, The Netherlands
Search for other works by this author on:
E. Moltzer,
E. Moltzer
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
K. van der Heiden,
K. van der Heiden
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
P. van Heijningen,
P. van Heijningen
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
A. F. W. van der Steen,
A. F. W. van der Steen
Erasmus MC, Rotterdam, The Netherlands
ICIN, Netherlands Heart Institute, Utrecht, The Netherlands
Search for other works by this author on:
J. Essers,
J. Essers
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
F. Gijsen,
F. Gijsen
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
J. Wentzel
J. Wentzel
Erasmus MC, Rotterdam, The Netherlands
Search for other works by this author on:
L. Speelman
Erasmus MC, Rotterdam, The Netherlands
ICIN, Netherlands Heart Institute, Utrecht, The Netherlands
E. Moltzer
Erasmus MC, Rotterdam, The Netherlands
K. van der Heiden
Erasmus MC, Rotterdam, The Netherlands
P. van Heijningen
Erasmus MC, Rotterdam, The Netherlands
A. F. W. van der Steen
Erasmus MC, Rotterdam, The Netherlands
ICIN, Netherlands Heart Institute, Utrecht, The Netherlands
J. Essers
Erasmus MC, Rotterdam, The Netherlands
F. Gijsen
Erasmus MC, Rotterdam, The Netherlands
J. Wentzel
Erasmus MC, Rotterdam, The Netherlands
Paper No:
SBC2012-80590, pp. 1275-1276; 2 pages
Published Online:
July 19, 2013
Citation
Speelman, L, Moltzer, E, van der Heiden, K, van Heijningen, P, van der Steen, AFW, Essers, J, Gijsen, F, & Wentzel, J. "Biomechanical Characteristics of Aortic Aneurysms Generated in Fibulin-4 Deficient Mice." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1275-1276. ASME. https://doi.org/10.1115/SBC2012-80590
Download citation file:
2
Views
0
Citations
Related Proceedings Papers
Related Articles
A Wireless, Passive Sensor for Monitoring the Pressure of an Abdominal Aortic Aneurysm Sac
J. Med. Devices (June,2008)
Computational Fluid–Structure Interactions in the Human Cerebrovascular System: Part 1—A Review of the Current Understanding of Cerebrovascular Biomechanics
ASME J of Medical Diagnostics (August,2022)
Related Chapters
PSA Level 2 — NPP Ringhals 2 (PSAM-0156)
Proceedings of the Eighth International Conference on Probabilistic Safety Assessment & Management (PSAM)
Generating Synthetic Electrocardiogram Signals Withcontrolled Temporal and Spectral Characteristics
Intelligent Engineering Systems through Artificial Neural Networks Volume 18
Influence of Measures of Risk Prevention and Mitigation on the Frequencies of Rupture of Pipework (PSAM-0392)
Proceedings of the Eighth International Conference on Probabilistic Safety Assessment & Management (PSAM)