Aortic aneurysms affect approximately 5% of the elderly population and aneurysm rupture is responsible for a significant number of deaths in the western world. Risk factors for aortic aneurysm include high cholesterol, high blood pressure, and smoking. Fibulin-4 is a glycoprotein, which is expressed in medial layers of blood vessels and a critical component for the structural integrity and elasticity of the aortic wall . Mice with reduced levels of Fibulin-4 develop aortic abnormalities similar to Fibulin-4 patients, such as dilation of the ascending aorta. A 4-fold reduction of Fibulin-4 expression (fib-4R/R) causes a severe dilation, while a mice with a 2-fold reduction (fib-4+/R) show an onset of aneurysm formation, comparable with the development of an aneurysm in aging humans .
- Bioengineering Division
Biomechanical Characteristics of Aortic Aneurysms Generated in Fibulin-4 Deficient Mice
- Views Icon Views
- Share Icon Share
- Search Site
Speelman, L, Moltzer, E, van der Heiden, K, van Heijningen, P, van der Steen, AFW, Essers, J, Gijsen, F, & Wentzel, J. "Biomechanical Characteristics of Aortic Aneurysms Generated in Fibulin-4 Deficient Mice." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1275-1276. ASME. https://doi.org/10.1115/SBC2012-80590
Download citation file: