To date, ligament and tendon replacements largely utilize autograft/allograft transplantation, although the use of tissue engineered materials remain a promising solution . The development of an engineered solution may depend on the choice of scaffold materials with optimal fiber alignment. Type I collagen is an abundant extracellular matrix component in musculoskeletal tissues. The controlled alignment of type I collagen for tissue engineering and regenerative medicine applications enables the fabrication of unique scaffolds that emulate the ultrastructure of their native counterparts. Moreover, the alignment of type I collagen has become a common technique to manipulate mechanical properties of tissue constructs and the biological response of embedded cells [1,2]. It is additionally important to develop noninvasive methods to align collagen structures while maintaining inherent structural integrity and biological activity.
- Bioengineering Division
Magnetic Alignment of Type I Collagen as a Method for Altering Tensile Mechanical Properties
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Novak, T, Canter, J, Chen, D, Hungate, J, Voytik-Harbin, S, & Neu, C. "Magnetic Alignment of Type I Collagen as a Method for Altering Tensile Mechanical Properties." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1227-1228. ASME. https://doi.org/10.1115/SBC2012-80907
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