Cryopreservation of engineered tissue equivalents (TE) has achieved limited success. Successful preservation of a functional TE or tissue could provide prolonged transplantation time windows or off-the-shelf availability of engineered tissues. A quantitative understanding of the freezing-induced cell-fluid-matrix mechanical interaction is critical towards successful preservation of functional tissue. Using quantum dot-mediated cell image deformetry, Teo et al have experimentally mapped the instantaneous deformation of a TE during freezing process and showed its resulting volume change after thawing due to fluid loss . To further our understanding of the freezing-induced fluid-matrix interaction, we have developed a biphasic model that simulates the transient of thermal load, its resulting TE elastic deformation, the corresponding pressure redistribution within, and the fluid movement in the TE.
- Bioengineering Division
A Biphasic Model Illuminating Freezing-Induced Fluid-Matrix Interactions in a Tissue Equivalent
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Wright, J, Han, B, & Chuong, C. "A Biphasic Model Illuminating Freezing-Induced Fluid-Matrix Interactions in a Tissue Equivalent." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 755-756. ASME. https://doi.org/10.1115/SBC2011-53321
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