Sustained mechanical loading of soft tissues covering bony prominences, as experienced by bedridden and wheelchair-bound individuals, may cause skeletal muscle damage. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, and progresses towards the skin. Damage pathways leading to DTI can involve ischemia, ischemia/reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, we have provided evidence that in a controlled animal model, deformation is the main trigger for damage within a 2h loading period [1,2]. However, ischemia and reperfusion may play a more important role in the damage process during prolonged loading periods.
- Bioengineering Division
Effect of Ischemia and Reperfusion on Skeletal Muscle Damage
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Loerakker, S, Manders, E, Strijkers, GJ, Baaijens, FPT, Bader, DL, Nicolay, K, & Oomens, CWJ. "Effect of Ischemia and Reperfusion on Skeletal Muscle Damage." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 41-42. ASME. https://doi.org/10.1115/SBC2010-19341
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