Convection-enhanced delivery is a means to deliver therapeutic agents directly into brain tissue. Biphasic models have been used to study the concomitant fluid and mass transport that occurs during infusion, however previous studies have been limited by the assumption of linear elasticity of the solid phase . In contrast, nonlinear stress-strain curves have been documented for brain tissue under finite deformation in tension and compression [2, 3].
- Bioengineering Division
A Nonlinear Biphasic Model for Mass Transport During Constant Flow-Rate Infusion Into Brain Tissue
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Smith, JH, & García, JJ. "A Nonlinear Biphasic Model for Mass Transport During Constant Flow-Rate Infusion Into Brain Tissue." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 133-134. ASME. https://doi.org/10.1115/SBC2010-19198
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