Mechanical stretch regulates many cell functions, including proliferation, apoptosis, migration and morphology that occur in response to stretch-induced changes in intracellular signaling and gene expression. We have previously reported that the temporal pattern of stretch-induced JNK activation is highly dependent on the spatiotemporal pattern of stretch that is applied. Specifically, cyclic uniaxial stretch causes a transient activation of JNK that subsides as their actin stress fibers (SFs) become oriented perpendicular to the direction of stretch, while cyclic equibiaxial stretch causes a sustained activation of JNK and does not induce SF orientation (1).
- Bioengineering Division
A Kinematic Model Coupling Cytoskeletal Dynamics With JNK Activation in Response to Matrix Stretching
- Views Icon Views
- Share Icon Share
- Search Site
Kaunas, R, Huang, Z, & Hahn, J. "A Kinematic Model Coupling Cytoskeletal Dynamics With JNK Activation in Response to Matrix Stretching." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 91-92. ASME. https://doi.org/10.1115/SBC2009-205635
Download citation file: