Paraffin wax histology analysis is treated as a golden standard to verify biological tissue microstructure. To generate a histology section, the tissue is subject to a sequence of dehydration processes to remove water from the tissue and replace it by wax to maintain the internal tissue structure. This process normally generates significant shrinkage in the specimen , adding uncertainties on quantifying region sizes based on histology sections, such as the area of lipid region, fibrous cap thickness (FCT) in human arterial plaque specimens.
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Assessment of Structure Distortion of Paraffin Wax Histology Section of Human Carotid Atherosclerotic Plaque Specimen
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Luppi, M, Gao, H, Choudhury, A, Hopkins, W, Das, S, Pinelli, M, & Long, Q. "Assessment of Structure Distortion of Paraffin Wax Histology Section of Human Carotid Atherosclerotic Plaque Specimen." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 847-848. ASME. https://doi.org/10.1115/SBC2009-206691
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