In the last two decades, decellularized native aortic valve (AV) has been investigated as tissue engineered heart valve (TEHV) replacements due to their potential to develop into a viable valve. Decellularization removes major immunogenic cellular components. After repopulated with recipient’s cells, TEHV can be readily used because of the necessary functional design. However, several problems with this approach have been identified, such as insufficient cell infiltration, mechanical deterioration, formation of fibrous sheath on implantation, and reduced orifice area after surgery.
- Bioengineering Division
The Intrinsic Durability of Aortic Valve ECM in Absence of Cellular Maintenance
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Liao, J, Joyce, EM, Jones, HL, Tahai, M, Borazjani, A, Merryman, WD, & Sacks, MS. "The Intrinsic Durability of Aortic Valve ECM in Absence of Cellular Maintenance." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 659-660. ASME. https://doi.org/10.1115/SBC2008-193110
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