The efficacy of chemotherapy is significantly impaired by multi-drug resistance (MDR) of cancer cells. The mechanism of MDR is associated with the overexpression of certain ATP-binding cassette protein transporters in plasma membranes. These transporters actively keep intracellular drug concentration below the cell-killing threshold by extruding cytotoxic drugs. Various strategies to overcome MDR have been proposed and have shown promising results at the laboratory level. However, pharmacokinetic alteration of co-administered anticancer agents reduces their clinical effectiveness. This leads to increased toxicity and undesirable side effects at effective concentrations . Hence, a clinically feasible strategy to overcome the phenomenon of MDR is highly desired.
- Bioengineering Division
Freezing-Assisted Intracellular Drug Delivery to Multi-Drug Resistant Cancer Cells
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Teo, KY, & Han, B. "Freezing-Assisted Intracellular Drug Delivery to Multi-Drug Resistant Cancer Cells." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 271-272. ASME. https://doi.org/10.1115/SBC2008-192373
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