The collagen gel has been extensively studied as an in vitro model for soft tissue mechanics, cell-ECM interactions, and as a prototypical bioartificial tissue; a model of gel mechanics from a microstructural perspective is important for all of these . An earlier experimental study recorded the microstructural rearrangements during confined compression by interpreting the evolution of birefringence patterns within the gel . The patterns suggested that strain was transmitted by fiber rotation at interconnections and was non-uniform due to fluid permeation resistance, indicating that macroscopic gel mechanics arise from elastic interactions between the solid phase fibers and viscous interactions with fluid. A structure-based mathematical model to account for both the elastic and viscous response of tissue equivalents was developed.
Biphasic Structure-Based Modeling of Tissue Equivalent Mechanics
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Chandran, PL, Stylianopoulos, T, & Barocas, VH. "Biphasic Structure-Based Modeling of Tissue Equivalent Mechanics." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 409-410. ASME. https://doi.org/10.1115/SBC2007-176616
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