Understanding the loading of the hip joint and femur is a critical factor in understanding the progression of osteoarthritis (OA) and the mechanical factors influencing the outcome of total hip replacement surgery (THR). While in vivo transducers provide unique and valuable information about hip joint loading, they are limited to evaluating small numbers of postoperative THR patients. Musculoskeletal models, however, easily provide estimates of the hipjoint loads in larger patient populations with a variety of orthopedic conditions. Comparing the predicted forces with in vivo data is one approach to evaluating the results of such a model. The physiological phenomenon that bone changes in response to its loading environment presents an alternate method for evaluating modeled muscle forces. Validation of musculoskeletal models can be obtained by comparing femoral bone mineral density (BMD) patterns to the predicted forces. To evaluate muscle force predictions of a parametric three dimensional musculoskeletal model of the hip joint and femur, this study tested the hypothesis that the predicted abductor muscle force and greater trochanter BMD were significantly correlated and that the predicted contact force and proximal femur BMD were significantly correlated.

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