The clinical success of bone-interfacing orthopaedic and dental implants is dependent on adequate fixation of the implant by mechanical interlock with ingrown bone tissue (i.e., functional osseointegration). The rate and reliability with which osseointegration is achieved are influenced by a number of factors, including the surface geometry of the implant (Thomas and Cook, 1985; Simmons et al., 1999). However, the mechanisms by which implant surface geometry influences initial bone formation remain unresolved. Identifying the factors that allow bone-interfacing implants to osseointegrate more rapidly and reliably should lead to improvements in their use and design.

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