Liquid-liquid extraction techniques are one of the major tools in chemical engineering, analytical chemistry, and biology, especially in a system where two immiscible liquids have an interface solutes exchange between the two liquid phases along the interface up to a point where the concentration ratios in the two liquids reach their equilibrium values . In this paper, we propose to use room temperature ionic liquid (RTIL) as a second liquid phase for extraction, which forms immiscible interface with aqueous solutions. We demonstrate liquid-liquid extraction with the EWOD digital microfluidic device, two model extraction systems were tested. One is organic dye extracted from RTIL(1-butyl-3-methylimidazolium bis(trifluoromethanesulfonylimide or BMIMNTf2) to water and the other is iodine (I2) extracted from water to BMIMNTf2. Droplets of aqueous solution and BMIMNTf2 solution were generated on chip reservoir then transported for extraction and separated by EWOD actuation successfully.
- Nanotechnology Institute
Liquid-Liquid Extraction Based on Digital Microfluidics
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Moon, H, Kunchala, P, Nanayakkara, Y, & Armstrong, DW. "Liquid-Liquid Extraction Based on Digital Microfluidics." Proceedings of the ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASME 2009 7th International Conference on Nanochannels, Microchannels and Minichannels. Pohang, South Korea. June 22–24, 2009. pp. 137-141. ASME. https://doi.org/10.1115/ICNMM2009-82268
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