For more than 27 years, implanted vagus nerve stimulation (VNS) devices, with electric current outputs in the 1 to 3.5 mA range, have been developed for many health care applications, including epilepsy and heart disease . Mechanical compression approaches for VNS were administered under surgical conditions, using forceps, in the 1800’s . Outcomes such as Electrocardiogram (ECG) data, blood pressure (BP), and heart rate (HR) were evaluated. Also, non-invasive (NI) mechanical compression of the vagus nerve for various nervous system disorders using hand, thumb, finger and belt pressure was popular in the 1800’s . Cyberonics (now LivaNova) received the first FDA clearance for a surgically implanted electrical VNS device to treat refractory epilepsy in 1997.
Vagus Nerve Stimulation for Blood Pressure and Heart Rate Regulation
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O’Clock, GD, KenKnight, BH, & Tolkacheva, EG. "Vagus Nerve Stimulation for Blood Pressure and Heart Rate Regulation." Proceedings of the 2018 Design of Medical Devices Conference. 2018 Design of Medical Devices Conference. Minneapolis, Minnesota, USA. April 9–12, 2018. V001T01A004. ASME. https://doi.org/10.1115/DMD2018-6847
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