REVIEW ARTICLES: Mechanics Applied to Living Organisms

Interfacial Transport in Large and Small Blood Vessels

[+] Author and Article Information
S. Weinbaum

Department of Mechanical Engineering, The City College of the City University of New York, New York, NY 10031

Appl. Mech. Rev 43(5S), S109-S118 (May 01, 1990) doi:10.1115/1.3120789 History: Online April 30, 2009


In this paper we shall review some recent mathematical models which have led to new conceptual views of the ultrastructural pathways by which water, solutes and large molecules cross the endothelial interface between tissue and blood. In particular, we shall show how a sequence of models for the endothelium and underlying tissue in large arteries have finally led to the experimental discovery of the large pore via which LDL and other large molecules enter the artery wall and how a new three-dimensional model for the interendothelial cleft in capillaries might reconcile the several long standing paradoxes relating to the measured filtration and solute permeability coefficients in the transcapillary exchange of water and hydrophilic solutes in the microcirculation.

Copyright © 1990 by American Society of Mechanical Engineers
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